Prepared by wet phase inversion polyvinylidene fluoride (PVDF) hollow-fiber membrane of blood, by introducing in the casting solution of polyvinyl alcohol (PVA) reacted with glutaraldehyde Crosslinking, improving the hydrophilicity of membrane material. Study on PVDF solid content, addition of PEG on membrane properties such as impact. Results showed that the modified polyvinylidene fluoride (PVDF) hydrophilic membranes the blood increase, decrease protein adsorption capacity, good chemical stability. With the increase of PVDF solid content, the tensile performance enhancement, bursting pressure increases, water flux and membrane pore size decreases as the addition of PEG increases membrane mechanical properties change little, pure water flux significantly.